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The antibody against RNF181 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase RNF181 protein (2-153AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against RNF181 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase RNF181 protein (2-153AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human colon cancer using RNF181 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using RNF181 Antibody at dilution of 1:1002
| Cat.No | ADC-23810A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RNF181 |
| Target Synonyms | RNF181 antibody; HSPC238 antibody; E3 ubiquitin-protein ligase RNF181 antibody; EC 2.3.2.27 antibody; RING finger protein 181 antibody; RING-type E3 ubiquitin transferase RNF181 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human E3 ubiquitin-protein ligase RNF181 protein (2-153AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9P0P0 |
Uniprot Id
Q9P0P0
Target Species
Human
Target Name
RNF181
Target Full Name
E3 ubiquitin-protein ligase RNF181
Target Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Target Protein Families
RNF181 family
Target Tissue Specificity
Widely expressed, with highest levels in liver and heart and lowest levels in brain and skeletal muscle. Expressed in platelets (at protein level).
Target Synonyms
RNF181; HSPC238; E3 ubiquitin-protein ligase RNF181; EC 2.3.2.27; RING finger protein 181; RING-type E3 ubiquitin transferase RNF181
Target Background
RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).
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