Rabbit anti-Human RNF40 Polyclonal Antibody

Uniprot Id

O75150

Target Species

Human

Target Name

RNF40

Target Full Name

E3 ubiquitin-protein ligase BRE1B

Target Function

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.

Target Subcellular Location

Nucleus.

Target Protein Families

BRE1 family

Target Tissue Specificity

Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine.

Target Synonyms

95 kDa retinoblastoma associated protein; 95 kDa retinoblastoma protein binding protein; 95 kDa retinoblastoma-associated protein; BRE 1B; BRE1 B; BRE1 E3 ubiquitin ligase homolog B; BRE1-B; BRE1B; BRE1B_HUMAN; DKFZp686K191; E3 ubiquitin protein ligase BRE1B; E3 ubiquitin-protein ligase BRE1B; KIAA0661; MGC13051; Rb associated protein; RBP 95; RBP95; RING finger protein 40; Ring finger protein 40 E3 ubiquitin protein ligase; RNF 40; Rnf40; STARING

Target Background

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.