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The antibody against SAE1 was raised in rabbit using the Synthesized peptide derived from Internal of Human AOS1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
The antibody against SAE1 was raised in rabbit using the Synthesized peptide derived from Internal of Human AOS1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
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Immunofluorescence analysis of HuvEc cells, using AOS1 antibody.
Western blot analysis of extracts from 293 cells, using AOS1 antibody.2
Western blot analysis of extracts from Colo cells, HepG2 cells and 293 cells using AOS1 antibody. The lane on the left is treated with synthesized peptide.3
| Cat.No | ADC-42300A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SAE1 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from Internal of Human AOS1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UBE0 |
Uniprot Id
Q9UBE0
Target Species
Human
Target Name
SAE1
Target Full Name
SUMO-activating enzyme subunit 1
Target Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Target Subcellular Location
Nucleus.
Target Protein Families
Ubiquitin-activating E1 family
Target Tissue Specificity
Expression level increases during S phase and drops in G2 phase (at protein level).
Target Research Area
Cell Biology
Target Synonyms
Activator of SUMO1; AOS1; HSPC140; Sae1; SAE1_HUMAN; Sentrin/SUMO activating protein AOS1; SUA1; SUMO 1 activating enzyme E1 N subunit; SUMO 1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; Ubiquitin like protein SUMO1 activating enzyme; Ubiquitin-like 1-activating enzyme E1A; UBL E1A; UBLE1A
Target Background
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).
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