Rabbit anti-Human SAG Polyclonal Antibody, Biotin conjugated

Uniprot Id

P10523

Target Species

Human

Target Name

SAG

Target Full Name

S-arrestin

Target Function

Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.

Target Involvement

Night blindness, congenital stationary, Oguchi type 1 (CSNBO1); Retinitis pigmentosa 47 (RP47)

Target Subcellular Location

Cell projection, cilium, photoreceptor outer segment. Membrane; Peripheral membrane protein.

Target Protein Families

Arrestin family

Target Tissue Specificity

Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level).

Target Research Area

Neuroscience, Signal Transduction

Target Synonyms

48 kDa protein; Arrestin 1; Arrestin; ARRS_HUMAN; Retinal S antigen (48 KDa protein); Retinal S-antigen; Rod photoreceptor arrestin; RP47; S antigen; S antigen retina and pineal gland (arrestin); S arrestin; S-AG; S-arrestin; SAG

Target Background

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.