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The antibody against SAMD8 was raised in rabbit using the Recombinant Human Sphingomyelin synthase-related protein 1 protein (1-152AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against SAMD8 was raised in rabbit using the Recombinant Human Sphingomyelin synthase-related protein 1 protein (1-152AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human lymph node tissue using SAMD8 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using SAMD8 Antibody at dilution of 1:1002
| Cat.No | ADC-11770A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SAMD8 |
| Target Synonyms | SAMD8; Sphingomyelin synthase-related protein 1; SMSr; Ceramide phosphoethanolamine synthase; CPE synthase; Sterile alpha motif domain-containing protein 8; SAM domain-containing protein 8 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Sphingomyelin synthase-related protein 1 protein (1-152AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96LT4 |
Uniprot Id
Q96LT4
Target Species
Human
Target Name
SAMD8
Target Full Name
Sphingomyelin synthase-related protein 1
Target Function
Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
Sphingomyelin synthase family
Target Synonyms
SAMD8; Sphingomyelin synthase-related protein 1; SMSr; Ceramide phosphoethanolamine synthase; CPE synthase; Sterile alpha motif domain-containing protein 8; SAM domain-containing protein 8
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