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The antibody against SAR1B was raised in rabbit using the Synthesized peptide derived from internal of Human SAR1B. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
The antibody against SAR1B was raised in rabbit using the Synthesized peptide derived from internal of Human SAR1B. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
$297.00
Western blot analysis of extracts from LOVO cells and RAW264.7 cells, using SAR1B antibody.
Immunohistochemistry analysis of paraffin-embedded human placenta tissue using SAR1B antibody.2
| Cat.No | ADC-41201A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SAR1B |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human SAR1B. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y6B6 |
Uniprot Id
Q9Y6B6
Target Species
Human
Target Name
SAR1B
Target Full Name
Small COPII coat GTPase SAR1B
Target Function
GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis.
Target Involvement
Chylomicron retention disease (CMRD)
Target Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
Target Protein Families
Small GTPase superfamily, SAR1 family
Target Tissue Specificity
Expressed in many tissues including small intestine, liver, muscle and brain.
Target Synonyms
ANDD; CMRD; GTBPB; SARA2; SAR1B
Target Background
The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene.
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