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The antibody against SEM1 was raised in rabbit using the Recombinant Human 26S proteasome complex subunit SEM1 protein (1-70AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against SEM1 was raised in rabbit using the Recombinant Human 26S proteasome complex subunit SEM1 protein (1-70AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human prostate cancer using SEM1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung tissue using SEM1 Antibody at dilution of 1:1002
| Cat.No | ADC-21442A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SEM1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human 26S proteasome complex subunit SEM1 protein (1-70AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P60896 |
Uniprot Id
P60896
Target Species
Human
Target Name
SEM1
Target Full Name
26S proteasome complex subunit SEM1
Target Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells.
Target Subcellular Location
Nucleus.
Target Protein Families
DSS1/SEM1 family
Target Tissue Specificity
Expressed in limb bud, craniofacial primordia and skin.
Target Synonyms
SEM1; C7orf76; DSS1; SHFDG1; SHFM1; 26S proteasome complex subunit SEM1; 26S proteasome complex subunit DSS1; Deleted in split hand/split foot protein 1; Split hand/foot deleted protein 1; Split hand/foot malformation type 1 protein
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