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The antibody against SEMA5A was raised in rabbit using the Recombinant Human Semaphorin-5A protein (201-400AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against SEMA5A was raised in rabbit using the Recombinant Human Semaphorin-5A protein (201-400AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human lung tissue using SEMA5A Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using SEMA5A Antibody at dilution of 1:1002
| Cat.No | ADC-20365A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SEMA5A |
| Target Synonyms | SEMA5A antibody; SEMAF antibody; Semaphorin-5A antibody; Semaphorin-F antibody; Sema F antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Semaphorin-5A protein (201-400AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13591 |
Uniprot Id
Q13591
Target Species
Human
Target Name
SEMA5A
Target Full Name
Semaphorin-5A
Target Function
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Semaphorin family
Target Synonyms
SEMA5A; SEMAF; Semaphorin-5A; Semaphorin-F; Sema F
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