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The antibody against SIM2 was raised in rabbit using the Recombinant Human Single-minded homolog 2 protein (347-433AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against SIM2 was raised in rabbit using the Recombinant Human Single-minded homolog 2 protein (347-433AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-06630A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SIM2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Single-minded homolog 2 protein (347-433AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14190 |
Uniprot Id
Q14190
Target Species
Human
Target Name
SIM2
Target Full Name
Single-minded homolog 2
Target Function
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
Target Subcellular Location
Nucleus.
Target Research Area
Cancer
Target Synonyms
bHLHe15; Class E basic helix loop helix protein 15; Class E basic helix-loop-helix protein 15; MGC119447; SIM 2; SIM; Sim2; SIM2_HUMAN; Single minded homolog 2 (Drosophila); Single minded homolog 2; Single-minded homolog 2; Transcription factor SIM2
Target Background
This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.
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