Rabbit anti-Human SNX27 Polyclonal Antibody

Uniprot Id

Q96L92

Target Species

Human

Target Name

SNX27

Target Full Name

Sorting nexin-27

Target Function

Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.

Target Subcellular Location

Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products.

Target Protein Families

Sorting nexin family

Target Tissue Specificity

Widely expressed. Expressed in cells of hematopoietic origin (at protein level).

Target Synonyms

KIAA0488; Methamphetamine responsive transcript 1; MGC126871; MGC126873; MGC20471; MRT1; MY014; OTTHUMP00000042487; RP11-98D18.12; SNX27; SNX27_HUMAN; Sorting nexin family member 27; Sorting nexin-27