Rabbit anti-Human SON Polyclonal Antibody

The antibody against SON was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 850-950 of human SON (NP_001278340.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-06697A

Number

Cat.No	ADA-06697A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	SON
Target Synonyms	SON3; BASS1; DBP-5; NREBP; TOKIMS; C21orf50; SON	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, LO2	Application	ELISA, WB

Cat.No

ADA-06697A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

SON

Target Synonyms

SON3; BASS1; DBP-5; NREBP; TOKIMS; C21orf50; SON

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, LO2

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 850-950 of human SON (NP_001278340.1).	Target Species	Human
Immunogen Sequence	TMDSQMLATSSMDSQMLASGTMDSQMLASGTMDAQMLASGTMDAQMLASSTQDSAMLGSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYR	Uniprot ID	P18583

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 850-950 of human SON (NP_001278340.1).

Target Species

Human

Immunogen Sequence

TMDSQMLATSSMDSQMLASGTMDSQMLASGTMDAQMLASGTMDAQMLASSTQDSAMLGSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYR

Uniprot ID

P18583

Background Information

Uniprot Id

P18583
Target Species

Human
Target Name

SON
Target Full Name

Protein SON
Target Function

RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1
Target Involvement

ZTTK syndrome (ZTTKS)
Target Subcellular Location

Nucleus speckle. Note=Colocalizes with the pre-mRNA splicing factor SRSF2.
Target Tissue Specificity

Widely expressed, with the higher expression seen in leukocyte and heart.
Target Synonyms

BASS1; Bax antagonist selected in saccharomyces 1; DBP-5; Negative regulatory element-binding protein; NRE-binding protein; Protein DBP-5; Protein SON; SON; SON protein; SON_HUMAN; SON3

Rabbit anti-Human SON Polyclonal Antibody

Specifications

Immunogen Information

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