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The antibody against SPATA2 was raised in rabbit using the Human SPATA2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against SPATA2 was raised in rabbit using the Human SPATA2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-51764A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SPATA2 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Human SPATA2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UM82 |
Uniprot Id
Q9UM82
Target Species
Human
Target Name
SPATA2
Target Full Name
Spermatogenesis-associated protein 2
Target Function
Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD. Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
SPATA2 family
Target Tissue Specificity
Present at high level in Sertoli cells, but not detected in spermatogenic cells (at protein level). Low expression in spleen, thymus and prostate.
Target Synonyms
FLJ13167; KIAA0757; PD 1; PD1; PPP1R145; Protein phosphatase 1 regulatory subunit 145; SPAT2_HUMAN; SPATA 2; SPATA2; Spermatogenesis associated 2; Spermatogenesis associated PD1; Spermatogenesis associated protein 2; Spermatogenesis associated protein PD1; Spermatogenesis-associated protein 2; Spermatogenesis-associated protein PD1; Tamo
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