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The antibody against SPC24 was raised in rabbit using the Recombinant Human Kinetochore protein Spc24 protein (21-97AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against SPC24 was raised in rabbit using the Recombinant Human Kinetochore protein Spc24 protein (21-97AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using SPC24 Antibody at dilution of 1:100
| Cat.No | ADC-15158A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SPC24 |
| Target Synonyms | homolog (S. cerevisiae) antibody; SPC24_HUMAN antibody; Spindle pole body component 24 homolog (S. cerevisiae) antibody; Spindle pole body component 24 homolog antibody, NDC80 kinetochore complex component | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Kinetochore protein Spc24 protein (21-97AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NBT2 |
Uniprot Id
Q8NBT2
Target Species
Human
Target Name
SPC24
Target Full Name
Kinetochore protein Spc24
Target Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Target Subcellular Location
Nucleus. Chromosome, centromere, kinetochore.
Target Protein Families
SPC24 family
Target Synonyms
FLJ90806; hSpc24; Kinetochore protein Spc24; SPBC24; spc24; SPC24 NDC80 kinetochore complex component; SPC24 NDC80 kinetochore complex component homolog; SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); SPC24_HUMAN; Spindle pole body component 24 homolog (S. cerevisiae); Spindle pole body component 24 homolog
Target Background
Predicted to be involved in cell division. Located in nucleolus and nucleoplasm. Part of Ndc80 complex.
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