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The antibody against SPRY4 was raised in rabbit using the Recombinant Human Protein sprouty homolog 4 protein (1-299AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against SPRY4 was raised in rabbit using the Recombinant Human Protein sprouty homolog 4 protein (1-299AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
$299.00
| Cat.No | ADC-22411A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SPRY4 |
| Target Synonyms | Protein sprouty homolog 4 antibody; Sprouty 4 antibody; Sprouty homolog 4 antibody; sprouty homolog 4 (Drosophila) antibody; SPRY 4 antibody; Spry-4 antibody; Spry4 antibody; SPY4_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein sprouty homolog 4 protein (1-299AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9C004 |
Uniprot Id
Q9C004
Target Species
Human
Target Name
SPRY4
Target Full Name
Protein sprouty homolog 4
Target Function
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1. Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin.
Target Involvement
Hypogonadotropic hypogonadism 17 with or without anosmia (HH17)
Target Subcellular Location
Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families
Sprouty family
Target Synonyms
Protein sprouty homolog 4; Sprouty 4; Sprouty homolog 4; sprouty homolog 4 (Drosophila); SPRY 4; Spry-4; Spry4; SPY4_HUMAN
Target Background
This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants.
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