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The antibody against SPTBN1 was raised in rabbit using the Recombinant Human Spectrin beta chain, non-erythrocytic 1 protein (2096-2256AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against SPTBN1 was raised in rabbit using the Recombinant Human Spectrin beta chain, non-erythrocytic 1 protein (2096-2256AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-06574A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SPTBN1 |
| Target Synonyms | beta, non erythrocytic 1 antibody; Spectrin, non erythroid beta chain 1 antibody; SPTB2 antibody; SPTB2_HUMAN antibody; SPTBN1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Spectrin beta chain, non-erythrocytic 1 protein (2096-2256AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q01082 |
Uniprot Id
Q01082
Target Species
Human
Target Name
SPTBN1
Target Full Name
Spectrin beta chain, non-erythrocytic 1
Target Function
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Target Subcellular Location
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, M line.; [Isoform 2]: Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families
Spectrin family
Target Tissue Specificity
Isoform 2 is present in brain, lung and kidney (at protein level).
Target Synonyms
ELF; SPTB2; DDISBA; HEL102; betaSpII; SPTBN1
Target Background
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene.
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