Rabbit anti-Human ST14 Polyclonal Antibody

Uniprot Id

Q9Y5Y6

Target Species

Human

Target Name

ST14

Target Full Name

Suppressor of tumorigenicity 14 protein

Target Function

Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.

Target Involvement

Ichthyosis, congenital, autosomal recessive 11 (ARCI11)

Target Subcellular Location

Membrane; Single-pass type II membrane protein.

Target Protein Families

Peptidase S1 family

Target Synonyms

HAI; CAP3; MTSP1; SNC19; ARCI11; MT-SP1; PRSS14; TADG15; TMPRSS14; ST14

Target Background

The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.