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The antibody against ST6GALNAC6 was raised in rabbit using the Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 protein (65-333AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against ST6GALNAC6 was raised in rabbit using the Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 protein (65-333AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human kidney tissue using ST6GALNAC6 Antibody at dilution of 1:100
| Cat.No | ADC-23411A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ST6GALNAC6 |
| Target Synonyms | 6-sialyltransferase 6 antibody; EC 2.4.99.- antibody; GalNAc alpha-2, 6-sialyltransferase VI antibody; ST6GalNAc VI antibody; ST6GalNAcVI antibody; hST6GalNAc VI antibody; Sialyltransferase 7F antibody; SIAT7-F antibody, ST6GALNAC6 antibody; SIAT7F antibody; UNQ708/PRO1359 antibody; Alpha-N-acetylgalactosaminide alpha-2 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 protein (65-333AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q969X2 |
Uniprot Id
Q969X2
Target Species
Human
Target Name
ST6GALNAC6
Target Full Name
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Target Function
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen. Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside).
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyltransferase 29 family
Target Tissue Specificity
Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines.
Target Synonyms
ST6GALNAC6; SIAT7F; UNQ708/PRO1359; Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; EC 2.4.99.-; GalNAc alpha-2,6-sialyltransferase VI; ST6GalNAc VI; ST6GalNAcVI; hST6GalNAc VI; Sialyltransferase 7F; SIAT7-F
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