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The antibody against STYX was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-223 of human STYX (NP_660294.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against STYX was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-223 of human STYX (NP_660294.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05141A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | STYX |
| Target Synonyms | STYX | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-431, A-549, HepG2 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-223 of human STYX (NP_660294.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8WUJ0 | Immunogen Sequence |
Uniprot Id
Q8WUJ0
Target Species
Human
Target Name
STYX
Target Full Name
Serine/threonine/tyrosine-interacting protein
Target Function
Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates. Plays a role in spermatogenesis.
Target Subcellular Location
Nucleus. Cytoplasm, cytosol.
Target Protein Families
Protein-tyrosine phosphatase family, Non-receptor class subfamily
Target Synonyms
Protein tyrosine phosphatase like protein ; Protein tyrosine phosphatase-like protein; Serine/threonine/tyrosine interacting protein; Serine/threonine/tyrosine-interacting protein; Styx; STYX_HUMAN
Target Background
The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes.
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