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The antibody against SYCP3 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human SCP-3. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against SYCP3 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human SCP-3. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
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Western Blot analysis of K562 22RV-1 H460 cells using SCP-3 Polyclonal Antibody
| Cat.No | ADC-37231A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SYCP3 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human SCP-3. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IZU3 |
Uniprot Id
Q8IZU3
Target Species
Human
Target Name
SYCP3
Target Full Name
Synaptonemal complex protein 3
Target Function
Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.
Target Involvement
Spermatogenic failure 4 (SPGF4); Pregnancy loss, recurrent, 4 (RPRGL4)
Target Subcellular Location
Nucleus. Chromosome. Chromosome, centromere.
Target Protein Families
XLR/SYCP3 family
Target Tissue Specificity
Testis-specific.
Target Synonyms
choline phosphotransferase 1; chpt1; COR 1; COR1; MGC71888; RNASCP3; SCP 3; SCP-3; SCP3; SPGF4; Sycp 3; Sycp3; SYCP3_HUMAN; Synaptonemal complex protein 3
Target Background
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein.
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