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The antibody against TAF6 was raised in rabbit using the Recombinant Human Transcription initiation factor TFIID subunit 6 protein (627-677AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against TAF6 was raised in rabbit using the Recombinant Human Transcription initiation factor TFIID subunit 6 protein (627-677AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human prostate cancer using TAF6 Antibody at dilution of 1:100
| Cat.No | ADC-15657A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TAF6 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Transcription initiation factor TFIID subunit 6 protein (627-677AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P49848 |
Uniprot Id
P49848
Target Species
Human
Target Name
TAF6
Target Full Name
Transcription initiation factor TFIID subunit 6
Target Function
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.; Transcriptional regulator which acts primarily as a positive regulator of transcription. Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis. Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1. In contrast, down-regulates transcription of MDM2. Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1. Can also activate transcription and apoptosis independently of TP53. Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA.
Target Involvement
Alazami-Yuan syndrome (ALYUS)
Target Subcellular Location
Nucleus.; [Isoform 4]: Nucleus.
Target Protein Families
TAF6 family
Target Synonyms
TAF6; TAF2E; TAFII70; Transcription initiation factor TFIID subunit 6; RNA polymerase II TBP-associated factor subunit E; Transcription initiation factor TFIID 70 kDa subunit; TAF(II)70; TAFII-70; TAFII70; Transcription initiation factor TFIID 80 kDa subunit; TAF(II)80; TAFII-80; TAFII80
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