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The antibody against TDRD9 was raised in rabbit using the Recombinant Human Putative ATP-dependent RNA helicase TDRD9 protein (286-585AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against TDRD9 was raised in rabbit using the Recombinant Human Putative ATP-dependent RNA helicase TDRD9 protein (286-585AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using TDRD9 Antibody at dilution of 1:100
| Cat.No | ADC-18642A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TDRD9 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Putative ATP-dependent RNA helicase TDRD9 protein (286-585AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NDG6 |
Uniprot Id
Q8NDG6
Target Species
Human
Target Name
TDRD9
Target Full Name
ATP-dependent RNA helicase TDRD9
Target Function
ATP-binding RNA helicase required during spermatogenesis. Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4.
Target Involvement
Defects in TDRD9 may be a cause of non-obstructive azoospermia, a disorder characterized by the absence of sperm. Female fertility is not affected.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
DEAD box helicase family, DEAH subfamily
Target Synonyms
C14orf75; chromosome 14 open reading frame 75; DKFZp434N0820; FLJ36164; HIG 1; Hypoxia inducible HIG 1; MGC135025; NET54; Putative ATP dependent RNA helicase TDRD9; Putative ATP-dependent RNA helicase TDRD9; TDRD 9; Tdrd9; TDRD9_HUMAN; Tudor domain containing 9; Tudor domain containing protein 9; Tudor domain-containing protein 9
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