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The antibody against THOC3 was raised in rabbit using the Recombinant Human THO complex subunit 3 protein (2-351AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against THOC3 was raised in rabbit using the Recombinant Human THO complex subunit 3 protein (2-351AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human colon cancer using THOC3 Antibody at dilution of 1:100
| Cat.No | ADC-19132A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | THOC3 |
| Target Synonyms | hTREX45 antibody; TEX1 homolog antibody; THO complex subunit 3 antibody; Tho3 antibody; THOC3 antibody; THOC3_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human THO complex subunit 3 protein (2-351AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96J01 |
Uniprot Id
Q96J01
Target Species
Human
Target Name
THOC3
Target Full Name
THO complex subunit 3
Target Function
Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Target Subcellular Location
Nucleus. Nucleus speckle.
Target Synonyms
hTREX45; TEX1 homolog; THO complex subunit 3; Tho3; THOC3; THOC3_HUMAN
Target Background
This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5.
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