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The antibody against THRA was raised in rabbit using the Recombinant Human Thyroid hormone receptor alpha protein (1-490AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against THRA was raised in rabbit using the Recombinant Human Thyroid hormone receptor alpha protein (1-490AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human colon cancer using THRA Antibody at dilution of 1:1002
| Cat.No | ADC-44056A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | THRA |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Thyroid hormone receptor alpha protein (1-490AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P10827 |
Uniprot Id
P10827
Target Species
Human
Target Name
THRA
Target Full Name
Thyroid hormone receptor alpha
Target Function
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.; Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
Target Involvement
Hypothyroidism, congenital, non-goitrous, 6 (CHNG6)
Target Subcellular Location
Nucleus.; [Isoform Alpha-2]: Cytoplasm. Nucleus.
Target Protein Families
Nuclear hormone receptor family, NR1 subfamily
Target Research Area
Neuroscience
Target Synonyms
c-erbA-1; C-erbA-alpha; EAR-7; ERBA 1; ERBA; ERBA related 7; Nuclear receptor subfamily 1 group A member 1; THA_HUMAN; THRA; Thra1; Thra2; Thyroid hormone receptor alpha 1; Thyroid hormone receptor alpha 2; Thyroid hormone receptor alpha; TR alpha 1; TR alpha 2; Tra1; Triiodothyronine receptor; V-erbA-related protein 7
Target Background
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
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