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The antibody against TMEM106B was raised in rabbit using the Human TMEM106B as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against TMEM106B was raised in rabbit using the Human TMEM106B as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-51573A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TMEM106B |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.02% sodium azide |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Human TMEM106B | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NUM4 |
Uniprot Id
Q9NUM4
Target Species
Human
Target Name
TMEM106B
Target Full Name
Transmembrane protein 106B
Target Function
Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.
Target Involvement
Ubiquitin-positive frontotemporal dementia (UP-FTD); Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 (FTDALS1)
Target Subcellular Location
Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor.
Target Protein Families
TMEM106 family
Target Tissue Specificity
Expressed in frontal cortex.
Target Synonyms
2310036D22Rik; 5830455K21Rik; 6430519M21Rik; AI428776; AI661344; FLJ11273; LRRGT00101; MGC33727; MGC94135; T106B_HUMAN; Tmem106b; Transmembrane protein 106B
Target Background
Enables ATPase binding activity. Involved in dendrite morphogenesis and lysosome localization. Located in endosome and lysosomal membrane. Implicated in hypomyelinating leukodystrophy.
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