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The antibody against TNIK was raised in rabbit using the Recombinant Human TRAF2 and NCK-interacting protein kinase protein (523-714AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TNIK was raised in rabbit using the Recombinant Human TRAF2 and NCK-interacting protein kinase protein (523-714AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human appendix tissue using TNIK Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using TNIK Antibody at dilution of 1:1002
Immunofluorescent analysis of Hela cells using TNIK Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-10727A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TNIK |
| Target Synonyms | EC 2.7.11.1 antibody; KIAA0551 antibody; Tnik antibody; TNIK_HUMAN antibody; Traf2 and NCK interacting kinase antibody; Traf2 and NCK-interacting protein kinase antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human TRAF2 and NCK-interacting protein kinase protein (523-714AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UKE5 |
Uniprot Id
Q9UKE5
Target Species
Human
Target Name
TNIK
Target Full Name
TRAF2 and NCK-interacting protein kinase
Target Function
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
Target Involvement
Mental retardation, autosomal recessive 54 (MRT54)
Target Subcellular Location
Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Target Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Target Tissue Specificity
Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
Target Synonyms
EC 2.7.11.1 ; KIAA0551 ; Tnik; TNIK_HUMAN; Traf2 and NCK interacting kinase; Traf2 and NCK-interacting protein kinase
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