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The antibody against TOLLIP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human TOLLIP (NP_061882.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TOLLIP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human TOLLIP (NP_061882.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10641A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TOLLIP |
| Target Synonyms | IL-1RAcPIP; [KD Validated] TOLLIP | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, Mouse brain, Mouse testis, Rat testis, SW620 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human TOLLIP (NP_061882.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9H0E2 | Immunogen Sequence |
Uniprot Id
Q9H0E2
Target Species
Human
Target Name
TOLLIP
Target Full Name
Toll-interacting protein
Target Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Tollip family
Target Synonyms
Adapter protein; FLJ33531; IL 1RAcPIP; IL1RAcPIP; TOLIP; TOLIP_HUMAN; Toll interacting protein; Toll-interacting protein; tollip
Target Background
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene.
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