Rabbit anti-Human TRDMT1 Polyclonal Antibody

Uniprot Id

O14717

Target Species

Human

Target Name

TRDMT1

Target Full Name

tRNA (cytosine(38)-C(5))-methyltransferase

Target Function

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).

Target Subcellular Location

Cytoplasm.

Target Protein Families

Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family

Target Tissue Specificity

Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes.

Target Synonyms

dDNMT; DmMT 2; DmMT2; DNA (cytosine 5 ) methyltransferase 2; DNA (cytosine 5) methyltransferase like protein 2; DNA (cytosine-5)-methyltransferase-like protein 2; DNA 5 cytosine methyltransferase; DNA methyltransferase 2; DNA methyltransferase homolog HsaIIP; DNA MTase homolog HsaIIP; Dnmt 2; Dnmt2; M.HsaIIP; MHsaIIP; nmt 2; nmt2; OTTHUMP00000045198; PuMet; RNMT 1; RNMT1; TRDMT 1; TRDMT_HUMAN; TRDMT1; tRNA (cytosine 5 ) methyltransferase; tRNA (cytosine(38)-C(5))-methyltransferase; tRNA aspartic acid methyltransferase 1; tRNA aspartic acid methyltransferase 1 variant 1; tRNA aspartic acid methyltransferase 1 variant 2; tRNA aspartic acid methyltransferase 1 variant 3; tRNA aspartic acid methyltransferase 1 variant 4; tRNA aspartic acid methyltransferase 1 variant 5; tRNA aspartic acid methyltransferase 1 variant 8

Target Background

This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa.