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The antibody against TRIM8 was raised in rabbit using the Recombinant Human Probable E3 ubiquitin-protein ligase TRIM8 protein (367-517AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TRIM8 was raised in rabbit using the Recombinant Human Probable E3 ubiquitin-protein ligase TRIM8 protein (367-517AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-06322A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRIM8 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Probable E3 ubiquitin-protein ligase TRIM8 protein (367-517AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BZR9 |
Uniprot Id
Q9BZR9
Target Species
Human
Target Name
TRIM8
Target Full Name
E3 ubiquitin-protein ligase TRIM8
Target Function
E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response. Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1. Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B. Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
TRIM/RBCC family
Target Tissue Specificity
Widely expressed.
Target Synonyms
AA408830; BB006755; GERP; Glioblastoma-expressed RING finger protein; Lioblastoma expressed ring finger protein; Probable E3 ubiquitin-protein ligase TRIM8; RING finger protein 27; RNF27; RP11-47A8.4; TRIM8; TRIM8_HUMAN; Tripartite motif containing 8; Tripartite motif protein TRIM8; Tripartite motif-containing protein 8
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