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The antibody against UVSSA was raised in rabbit using the Recombinant Human UV-stimulated scaffold protein A protein (143-206AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against UVSSA was raised in rabbit using the Recombinant Human UV-stimulated scaffold protein A protein (143-206AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-03509A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | UVSSA |
| Target Synonyms | hypothetical protein LOC57654 antibody; K1530_HUMAN antibody; KIAA1530 antibody; Uncharacterized protein KIAA1530 antibody; UV stimulated scaffold protein A antibody; UVSS3 antibody; UVSSA antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human UV-stimulated scaffold protein A protein (143-206AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q2YD98 |
Uniprot Id
Q2YD98
Target Species
Human
Target Name
UVSSA
Target Full Name
UV-stimulated scaffold protein A
Target Function
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.
Target Involvement
UV-sensitive syndrome 3 (UVSS3)
Target Subcellular Location
Chromosome.
Target Protein Families
UVSSA family
Target Synonyms
hypothetical protein LOC57654; K1530_HUMAN; KIAA1530; Uncharacterized protein KIAA1530; UV stimulated scaffold protein A; UVSS3; UVSSA
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