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The antibody against WNK2 was raised in rabbit using the Recombinant Human Serine/threonine-protein kinase WNK2 protein (1177-1464AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against WNK2 was raised in rabbit using the Recombinant Human Serine/threonine-protein kinase WNK2 protein (1177-1464AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human small intestine tissue using WNK2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostate tissue using WNK2 Antibody at dilution of 1:1002
Immunofluorescent analysis of HepG2 cells using WNK2 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-08975A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | WNK2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Serine/threonine-protein kinase WNK2 protein (1177-1464AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y3S1 |
Uniprot Id
Q9Y3S1
Target Species
Human
Target Name
WNK2
Target Full Name
Serine/threonine-protein kinase WNK2
Target Function
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
Target Subcellular Location
Cytoplasm. Cell membrane.
Target Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family, WNK subfamily
Target Tissue Specificity
Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon.
Target Synonyms
WNK2; KIAA1760; PRKWNK2; SDCCAG43; P/OKcl.13; Serine/threonine-protein kinase WNK2; EC 2.7.11.1; Antigen NY-CO-43; Protein kinase lysine-deficient 2; Protein kinase with no lysine 2; Serologically defined colon cancer antigen 43
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