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The antibody against WNK4 was raised in rabbit using the Recombinant Human Serine/threonine-protein kinase WNK4 protein (828-1106AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against WNK4 was raised in rabbit using the Recombinant Human Serine/threonine-protein kinase WNK4 protein (828-1106AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human kidney tissue using WNK4 Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using WNK4 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
Immunofluorescent analysis of PC-3 cells using WNK4 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-15136A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | WNK4 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Serine/threonine-protein kinase WNK4 protein (828-1106AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96J92 |
Uniprot Id
Q96J92
Target Species
Human
Target Name
WNK4
Target Full Name
Serine/threonine-protein kinase WNK4
Target Function
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition.
Target Involvement
Pseudohypoaldosteronism 2B (PHA2B)
Target Subcellular Location
Cell junction, tight junction.
Target Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family, WNK subfamily
Target Tissue Specificity
Expressed in kidney, colon and skin.
Target Synonyms
PHA 2B; PHA2B; PRKWNK 4; PRKWNK4; Protein kinase lysine deficient 4; Protein kinase lysine-deficient 4; Protein kinase with no lysine 4; Serine/threonine protein kinase WNK4; Serine/threonine-protein kinase WNK4; WNK lysine deficient protein kinase 4; Wnk4; WNK4_HUMAN
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