Rabbit anti-Human WNT1 Polyclonal Antibody

Uniprot Id

P04628

Target Species

Human

Target Name

WNT1

Target Full Name

Proto-oncogene Wnt-1

Target Function

Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis.

Target Involvement

Osteoporosis (OSTEOP); Osteogenesis imperfecta 15 (OI15); Osteogenesis imperfecta 14 (OI14)

Target Subcellular Location

Secreted, extracellular space, extracellular matrix. Secreted.

Target Protein Families

Wnt family

Target Research Area

Cancer

Target Synonyms

BMND16; INT1; OI15; oncogene Int1; Proto oncogene protein Wnt 1; Proto-oncogene Int-1 homolog; Proto-oncogene Wnt-1; Wingless type MMTV integration site family member 1; wingless-type MMTV integration site family; member 1 (oncogene INT1); Wnt 1; wnt1; WNT1_HUMAN

Target Background

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.