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The antibody against XRN2 was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human XRN2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against XRN2 was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human XRN2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
$167.00
Western Blot analysis of COS7 cells using XRN2 Polyclonal Antibody
| Cat.No | ADC-32751A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | XRN2 |
| Target Synonyms | XRN2 antibody; 5'-3' exoribonuclease 2 antibody; EC 3.1.13.- antibody; DHM1-like protein antibody; DHP protein antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Monkey | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the N-terminal region of Human XRN2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9H0D6 |
Uniprot Id
Q9H0D6
Target Species
Human
Target Name
XRN2
Target Full Name
5'-3' exoribonuclease 2
Target Function
Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites.
Target Subcellular Location
Nucleus, nucleolus.
Target Protein Families
5'-3' exonuclease family, XRN2/RAT1 subfamily
Target Tissue Specificity
Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.
Target Synonyms
XRN2; 5'-3' exoribonuclease 2; EC 3.1.13.-; DHM1-like protein; DHP protein
Target Background
This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms.
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