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The antibody against ZEB2 was raised in rabbit using the Synthesized peptide derived from internal of Human ZEB2. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
The antibody against ZEB2 was raised in rabbit using the Synthesized peptide derived from internal of Human ZEB2. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
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Western blot analysis of extracts from HepG2 cells, using ZEB2 antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using ZEB2 antibody.2
| Cat.No | ADC-42221A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZEB2 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human ZEB2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O60315 |
Uniprot Id
O60315
Target Species
Human
Target Name
ZEB2
Target Full Name
Zinc finger E-box-binding homeobox 2
Target Function
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. Represses expression of MEOX2.
Target Involvement
Mowat-Wilson syndrome (MOWS)
Target Subcellular Location
Nucleus. Chromosome.
Target Protein Families
Delta-EF1/ZFH-1 C2H2-type zinc-finger family
Target Synonyms
FLJ42816; HSPC082; KIAA0569; SIP 1; SIP1; Smad Interacting Protein 1; Smad-interacting protein 1; SMADIP 1; SMADIP1; ZEB 2; Zeb2; ZEB2_HUMAN; Zfhx1b; ZFHX1B protein; Zfx1b; Zinc finger E box binding protein 2; Zinc finger E-box-binding homeobox 2; Zinc finger homeobox 1b; zinc finger homeobox protein 1; Zinc finger homeobox protein 1b
Target Background
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.
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