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The antibody against Gdf5 was raised in rabbit using the Recombinant Mouse Growth/differentiation factor 5 protein (376-495AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against Gdf5 was raised in rabbit using the Recombinant Mouse Growth/differentiation factor 5 protein (376-495AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded mouse liver tissue using Gdf5 Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded human placenta tissue using Gdf5 Antibody at dilution of 1:202
| Cat.No | ADC-50912A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GDF5 |
| Target Synonyms | Gdf5 antibody; Bmp14 antibody; Bp antibody; Gdf-5Growth/differentiation factor 5 antibody; GDF-5 antibody; Bone morphogenetic protein 14 antibody; BMP-14 antibody | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Mouse Growth/differentiation factor 5 protein (376-495AA) | Target Species | Mus musculus (Mouse) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P43027 |
Uniprot Id
P43027
Target Species
Mouse
Target Name
GDF5
Target Full Name
Growth/differentiation factor 5
Target Function
Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Target Involvement
Defects in Gdf5 are the cause of brachypodism (bp) which alters the length and numbers of bones in the limbs but spares the axial skeleton.
Target Subcellular Location
Secreted. Cell membrane.
Target Protein Families
TGF-beta family
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