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Rabbit anti-Mus musculus (Mouse) Lypla1 Polyclonal Antibody, Biotin conjugated

The antibody against Lypla1 was raised in rabbit using the Recombinant Mouse Acyl-protein thioesterase 1 protein (1-230AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

ADC-46147A

The antibody against Lypla1 was raised in rabbit using the Recombinant Mouse Acyl-protein thioesterase 1 protein (1-230AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

$299.00

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Specifications


Cat.No ADC-46147A ClonalityPolyclonal
Host SpeciesRabbitTarget NameLypla1
FormLiquidSpecies ReactivityMouse
IsotypeIgGStorage Buffer0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4
Purification Method>95%, Protein G purifiedConjugateBiotin conjugated
ApplicationELISAStorageUpon receipt

Immunogen Information


Immunogen DescriptionRecombinant Mouse Acyl-protein thioesterase 1 protein (1-230AA)Target SpeciesMus musculus (Mouse)
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDP97823
Background Information
  • Uniprot Id

    P97823

  • Target Species

    Mouse

  • Target Name

    LYPLA1

  • Target Full Name

    Acyl-protein thioesterase 1

  • Target Function

    Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Could also depalmitoylate ADRB2. Acts as a lysophospholipase hydrolyzing various lysophospholipids including lysophosphatidylcholine (lyso-PC), lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS)(PubMed:9139730). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA.

  • Target Subcellular Location

    Cytoplasm. Cell membrane. Nucleus membrane. Endoplasmic reticulum.

  • Target Protein Families

    AB hydrolase superfamily, AB hydrolase 2 family

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