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Rabbit anti-Mus musculus (Mouse) Pcsk5 Polyclonal Antibody

The antibody against Pcsk5 was raised in rabbit using the Recombinant Mouse Proprotein convertase subtilisin/kexin type 5 protein (117-452AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

ADC-21720A

The antibody against Pcsk5 was raised in rabbit using the Recombinant Mouse Proprotein convertase subtilisin/kexin type 5 protein (117-452AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

$299.00

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Specifications


Cat.No ADC-21720A ClonalityPolyclonal
Host SpeciesRabbitTarget NamePcsk5
FormLiquidSpecies ReactivityMouse
IsotypeIgGStorage Buffer0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4
Purification Method>95%, Protein G purifiedConjugateNon-conjugated
ApplicationELISAStorageUpon receipt

Immunogen Information


Immunogen DescriptionRecombinant Mouse Proprotein convertase subtilisin/kexin type 5 protein (117-452AA)Target SpeciesMus musculus (Mouse)
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDQ04592
Background Information
  • Uniprot Id

    Q04592

  • Target Species

    Mouse

  • Target Name

    PCSK5

  • Target Full Name

    Proprotein convertase subtilisin/kexin type 5

  • Target Function

    Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors.

  • Target Subcellular Location

    [Isoform PC5A]: Secreted. Note=Secreted through the regulated secretory pathway.; [Isoform PC5B]: Endomembrane system; Single-pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.

  • Target Protein Families

    Peptidase S8 family

  • Target Tissue Specificity

    PC5A is expressed in most tissues but is most abundant in the intestine and adrenals. PC5B is expressed in the intestine, adrenals and lung but not in the brain.

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