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The antibody against Pcsk5 was raised in rabbit using the Recombinant Mouse Proprotein convertase subtilisin/kexin type 5 protein (117-452AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against Pcsk5 was raised in rabbit using the Recombinant Mouse Proprotein convertase subtilisin/kexin type 5 protein (117-452AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-21720A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Pcsk5 |
| Form | Liquid | Species Reactivity | Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Mouse Proprotein convertase subtilisin/kexin type 5 protein (117-452AA) | Target Species | Mus musculus (Mouse) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q04592 |
Uniprot Id
Q04592
Target Species
Mouse
Target Name
PCSK5
Target Full Name
Proprotein convertase subtilisin/kexin type 5
Target Function
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors.
Target Subcellular Location
[Isoform PC5A]: Secreted. Note=Secreted through the regulated secretory pathway.; [Isoform PC5B]: Endomembrane system; Single-pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.
Target Protein Families
Peptidase S8 family
Target Tissue Specificity
PC5A is expressed in most tissues but is most abundant in the intestine and adrenals. PC5B is expressed in the intestine, adrenals and lung but not in the brain.
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