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The antibody against Htra1 was raised in rabbit using the Recombinant Mouse Serine protease HTRA1 (Htra1), partial (141-480AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein A/G purified. This antibody has been validated on ELISA, WB.
The antibody against Htra1 was raised in rabbit using the Recombinant Mouse Serine protease HTRA1 (Htra1), partial (141-480AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein A/G purified. This antibody has been validated on ELISA, WB.
$299.00
Western Blot | Positive WB detected in Recombinant protein | All lanes: Htra1 antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 39 kDa | Observed band size: 40 kDa
| Cat.No | ADC-01733A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HTRA1 |
| Target Synonyms | Htra1 antibody; Htra antibody; Prss11 antibody; Serine protease HTRA1 antibody; EC 3.4.21.- antibody; High-temperature requirement A serine peptidase 1 antibody; Serine protease 11 antibody | Form | Liquid |
| Species Reactivity | Mus musculus | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Protein A/G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Mouse Serine protease HTRA1 (Htra1), partial (141-480AA) | Target Species | Mus musculus (Mouse) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9R118 |
Uniprot Id
Q9R118
Target Species
Mouse
Target Name
HTRA1
Target Full Name
Serine protease HTRA1
Target Function
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, but it is unclear whether it leads to the proteolytic degradation of TGF-beta proteins themselves or not. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Target Subcellular Location
Cell membrane. Secreted. Cytoplasm, cytosol.
Target Protein Families
Peptidase S1C family
Target Tissue Specificity
In the brain, mainly expressed in cortical areas both in glial cells and neurons (at protein level). In bones, deposited in the matrix, with higher level in newly formed bone compared to fully calcified bone (at protein level). Also expressed in the tendo
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