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The antibody against Prnp was raised in rabbit using the Recombinant Rat Major prion protein (29-231AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against Prnp was raised in rabbit using the Recombinant Rat Major prion protein (29-231AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-21614A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PRNP |
| Target Synonyms | Prnp antibody; Prn antibody; Prp antibody; Major prion protein antibody; PrP antibody; CD antigen CD230 antibody | Form | Liquid |
| Species Reactivity | Rat | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Rat Major prion protein (29-231AA) | Target Species | Rattus norvegicus (Rat) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P13852 |
Uniprot Id
P13852
Target Species
Rat
Target Name
PRNP
Target Full Name
Major prion protein
Target Function
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Target Involvement
Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.
Target Protein Families
Prion family
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