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The antibody against ARHGEF9 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human ARHGEF9. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
The antibody against ARHGEF9 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human ARHGEF9. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
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| Cat.No | ADC-35817A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ARHGEF9 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the C-terminal region of Human ARHGEF9. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O43307 |
Uniprot Id
O43307
Target Species
Human
Target Name
ARHGEF9
Target Full Name
Rho guanine nucleotide exchange factor 9
Target Function
Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
Target Involvement
Epileptic encephalopathy, early infantile, 8 (EIEE8)
Target Subcellular Location
Cytoplasm. Cell junction, synapse, postsynaptic density.
Target Tissue Specificity
Detected in brain. Detected at low levels in heart.
Target Synonyms
9630036L12Rik; A230067K14; ARHG9_HUMAN; Arhgef9; Cdc42 guanine nucleotide exchange factor (GEF) 9; Collybistin; collybistin I; EIEE8; HPEM 2; hPEM-2 collybistin; KIAA0424; mKIAA0424; OTTHUMP00000023424; OTTHUMP00000023425; OTTHUMP00000023427; PEM 2; PEM 2 homolog ; PEM-2 homolog; PEM2; Rac/Cdc42 guanine nucleotide exchange factor 9; Rho guanine nucleotide exchange factor 9; RP11 357C3.4; RP23 230K20.3
Target Background
The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. This brain-specific protein also acts as an adaptor protein for the recruitment of gephyrin and together these proteins facilitate receceptor recruitement in GABAnergic and glycinergic synapses. Defects in this gene are the cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy, as well as several other types of cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene.
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