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The antibody against BCKDK was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human BCKDK. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
The antibody against BCKDK was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human BCKDK. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
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Western Blot analysis of 3T3 cells using BCKDK Polyclonal Antibody
Western Blot analysis of NIH-3T3 K562 Jurkat cells using BCKDK Polyclonal Antibody2
| Cat.No | ADC-39238A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BCKDK |
| Target Synonyms | [3 methyl 2 oxobutanoate dehydrogenase [lipoamide]] kinase | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the N-terminal region of Human BCKDK. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O14874 |
Uniprot Id
O14874
Target Species
Human
Target Name
BCKDK
Target Full Name
Branched-chain alpha-ketoacid dehydrogenase kinase
Target Function
Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
Target Involvement
Branched-chain ketoacid dehydrogenase kinase deficiency (BCKDKD)
Target Subcellular Location
Mitochondrion matrix. Mitochondrion.
Target Protein Families
PDK/BCKDK protein kinase family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
[3 methyl 2 oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial ; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase; BCKD kinase ; BCKD-kinase; BCKD_HUMAN; BCKDHKIN; Bckdk; BCKDKD; BDK; Branched chain alpha keto acid dehydrogenase kinase; Branched chain ketoacid dehydrogenase kinase; Branched-chain alpha-ketoacid dehydrogenase kinase; mitochondrial
Target Background
The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene.
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