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The antibody against RIN1 was raised in rabbit using the Synthesized peptide derived from internal of Human RIN1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against RIN1 was raised in rabbit using the Synthesized peptide derived from internal of Human RIN1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
$297.00
Western blot analysis of extracts from K562 cells, using RIN1 antibody.
| Cat.No | ADC-40983A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RIN1 |
| Target Synonyms | RIN1 antibody; Ras and Rab interactor 1 antibody; Ras inhibitor JC99 antibody; Ras interaction/interference protein 1 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human RIN1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13671 |
Uniprot Id
Q13671
Target Species
Human
Target Name
RIN1
Target Full Name
Ras and Rab interactor 1
Target Function
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
Target Subcellular Location
Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.
Target Protein Families
RIN (Ras interaction/interference) family
Target Tissue Specificity
Expressed in all tissues examined with high levels in brain, placenta and pancreas.
Target Synonyms
RIN1; Ras and Rab interactor 1; Ras inhibitor JC99; Ras interaction/interference protein 1
Target Background
Predicted to enable small GTPase binding activity. Predicted to be involved in endocytosis; regulation of catalytic activity; and signal transduction. Predicted to act upstream of or within associative learning; memory; and negative regulation of synaptic plasticity. Located in cytoplasm and plasma membrane.
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