Rabbit anti-Human CREM Polyclonal Antibody

Uniprot Id

Q03060

Target Species

Human

Target Name

CREM

Target Full Name

cAMP-responsive element modulator

Target Function

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation.; May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.

Target Subcellular Location

Nucleus.; [Isoform 6]: Cytoplasm. Nucleus.

Target Protein Families

BZIP family

Target Tissue Specificity

Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.

Target Synonyms

ICER; CREM-2; hCREM-2; CREM

Target Background

This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.