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The antibody against RAB7B was raised in rabbit using the Recombinant Human Ras-related protein Rab-7b protein (100-199AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against RAB7B was raised in rabbit using the Recombinant Human Ras-related protein Rab-7b protein (100-199AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
$299.00
| Cat.No | ADC-05088A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RAB7B |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ras-related protein Rab-7b protein (100-199AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96AH8 |
Uniprot Id
Q96AH8
Target Species
Human
Target Name
RAB7B
Target Full Name
Ras-related protein Rab-7b
Target Function
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
Target Subcellular Location
Late endosome. Lysosome. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.
Target Protein Families
Small GTPase superfamily, Rab family
Target Tissue Specificity
Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.
Target Synonyms
MGC16212; MGC9726; RAB7; rab7B; RAB7B; member RAS oncogene family ; RAB7B_HUMAN; Ras related protein Rab 7b; Ras-related protein Rab-7B
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