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The antibody against IAPP was raised in rabbit using the Recombinant Human Islet amyloid polypeptide protein (34-70AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against IAPP was raised in rabbit using the Recombinant Human Islet amyloid polypeptide protein (34-70AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human pancreatic tissue using IAPP Antibody at dilution of 1:100
| Cat.No | ADC-46411A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IAPP |
| Target Synonyms | amylin) antibody; Islet amyloid polypeptide antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Islet amyloid polypeptide protein (34-70AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P10997 |
Uniprot Id
P10997
Target Species
Human
Target Name
IAPP
Target Full Name
Islet amyloid polypeptide
Target Function
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Target Subcellular Location
Secreted.
Target Protein Families
Calcitonin family
Target Research Area
Signal Transduction
Target Synonyms
Amylin; DAP; Diabetes associated peptide; Diabetes-associated peptide; IAP; IAPP; IAPP_HUMAN; Insulinoma amyloid peptide; Islet amyloid polypeptide (diabetes associated peptide, amylin); Islet amyloid polypeptide
Target Background
This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity.
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