Rabbit anti-Human TNNI1 Polyclonal Antibody

Uniprot Id

P19237

Target Species

Human

Target Name

TNNI1

Target Full Name

Troponin I, slow skeletal muscle

Target Function

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Target Protein Families

Troponin I family

Target Tissue Specificity

Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myotubes.

Target Synonyms

2700018B22Rik; AI747285; DKFZp451O223 ; si:dz182n13.3; slow skeletal muscle; slow-twitch isoform; SSTNI; TNN1; Tnni1; TNNI1_HUMAN; Troponin I; Troponin I slow skeletal muscle; Troponin I slow twitch isoform ; troponin I type 1 (skeletal; slow); Troponin I; slow isoform

Target Background

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.