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The antibody against Disintegrin EC3B was raised in rabbit using the Recombinant Echis carinatus Disintegrin EC3B protein (1-67AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against Disintegrin EC3B was raised in rabbit using the Recombinant Echis carinatus Disintegrin EC3B protein (1-67AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-49891A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Disintegrin EC3B |
| Target Synonyms | Disintegrin EC3B antibody | Form | Liquid |
| Species Reactivity | Echis carinatus | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Echis carinatus Disintegrin EC3B protein (1-67AA) | Target Species | Echis carinatus |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P81631 |
Uniprot Id
P81631
Target Species
Echis carinatus
Target Function
Inhibits adhesion of cells expressing alpha-4/beta-1 (ITGA4/ITGB1) and alpha-4/beta-7 (ITGA4/ITGB7) integrins to the natural ligands vascular cell adhesion molecule 1 (VCAM-1) and mucosal addressin cell adhesion molecule 1 (MADCAM-1). It is also a weaker inhibitor of alpha-5/beta-1 (ITGA5/ITGB1) and alpha-2b/beta-3 (ITGA2B/ITGB3) integrins. The inhibitory activity of EC3 towards alpha-4 integrins is associated with the MLD sequence of EC3B subunit. The ability of EC3 to inhibit ITGA5/ITGB1 resides in both subunits A and B.
Target Subcellular Location
Secreted.
Target Protein Families
Venom metalloproteinase (M12B) family, P-II subfamily, P-IIe sub-subfamily
Target Tissue Specificity
Expressed by the venom gland.
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