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The antibody against DVL2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human DVL2 (NP_004413.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
The antibody against DVL2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human DVL2 (NP_004413.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
Immunofluorescence analysis of U2OS cells using DVL2 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
| Cat.No | ADA-00006A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DVL2 |
| Target Synonyms | DVL2 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human DVL2 (NP_004413.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O14641 | Immunogen Sequence |
Uniprot Id
O14641
Target Species
Human
Target Name
DVL2
Target Full Name
Segment polarity protein dishevelled homolog DVL-2
Target Function
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
Target Subcellular Location
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle. Nucleus.
Target Protein Families
DSH family
Target Synonyms
Dishevelled 2 (homologous to Drosophila dsh); Dishevelled dsh homolog 2; dishevelled segment polarity protein 2; Dishevelled-2; Dishevelled2; DSH homolog 2; DVL 2; Dvl2; DVL2_HUMAN; Segment polarity protein dishevelled homolog DVL 2; Segment polarity protein dishevelled homolog DVL-2; Segment polarity protein dishevelled homolog DVL2
Target Background
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
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