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The antibody against HIP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 410-690 of human HIP1 (NP_005329.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against HIP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 410-690 of human HIP1 (NP_005329.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02790A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HIP1 |
| Target Synonyms | SHON; HIP-I; ILWEQ; SHONbeta; SHONgamma; HIP1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, A-549, BT-474, Mouse brain, SW480 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 410-690 of human HIP1 (NP_005329.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O00291 | Immunogen Sequence |
Uniprot Id
O00291
Target Species
Human
Target Name
HIP1
Target Full Name
Huntingtin-interacting protein 1
Target Function
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
Target Involvement
A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB (PubMed:9616134). The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes (PubMed:9616134). The reciprocal PDGFRB-HIP1 transcript is not expressed (PubMed:9616134).
Target Subcellular Location
Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
Target Protein Families
SLA2 family
Target Tissue Specificity
Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
Target Synonyms
2610109B09Rik; A930014B11Rik; E130315I21Rik; HIP 1; HIP I; HIP-1; HIP-I; hip1; HIP1/PDGFRB fusion gene; HIP1/PDGFRB fusion gene, included; HIP1_HUMAN; HIPI; Huntingtin interacting protein 1; Huntingtin Interacting Protein HIP1; Huntingtin-interacting protein 1; Huntingtin-interacting protein I; ILWEQ; KIAA4113; MGC126506; MGC27616; mKIAA4113
Target Background
The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants.
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