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The antibody against INTS4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human INTS4 (NP_291025.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ELISA.
The antibody against INTS4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human INTS4 (NP_291025.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ELISA.
| Cat.No | ADA-03075A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | INTS4 |
| Target Synonyms | INT4; MST093; INTS4 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HepG2, Jurkat, Mouse testis, Rat liver | Application | ELISA, WB, IP |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human INTS4 (NP_291025.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96HW7 | Immunogen Sequence |
Uniprot Id
Q96HW7
Target Species
Human
Target Name
INTS4
Target Full Name
Integrator complex subunit 4
Target Function
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
Target Subcellular Location
Nucleus.
Target Protein Families
Integrator subunit 4 family
Target Synonyms
Int4; INT4_HUMAN; Integrator complex subunit 4; ints4; MGC16733; MST093; MSTP093; RGD1305036
Target Background
INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).
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